Copper Tripeptide

Product Overview

Copper Tripeptide-1, also known as GHK-Cu or Blue Copper Peptide in the cosmetics industry, is a top-notch peptide ingredient for skincare that works well. It is a key ingredient in modern, high-performance products that address the visible indications of aging and environmental stress since it is a strong skin-conditioning agent (INCI).

This substance, with the CAS number 49557-75-7, comes in the form of a signature, very pure blue crystalline powder. Our manufacturing procedure makes sure that the purity level is at least 99%, as shown by HPLC. This guarantees that your formulation will be as active as possible and consistent from batch to batch.

Solubility is a big problem for formulators who work with peptides. Our GHK-Cu fixes this problem by being very soluble in water (≥100mg/ml). This makes it easy to mix into serums, toners, and emulsions that are water-based. The outcome is a crystal-clear, beautiful blue solution that doesn’t have any problems with stability or clarity.

High-end manufacturers want GHK-Cu because it can make skin look firmer, more elastic, and smoother overall. It is an important ingredient in products that are meant to make fine lines and wrinkles less noticeable and give the skin a soothed, refreshed look.

Key Advantages:

• Ultra-High Purity: ≥99% by High-Performance Liquid Chromatography (HPLC) (Typical Batch: 99.12%), ensuring minimal impurities and maximum efficacy.
• Verified Identity: Authenticity confirmed by ESI-MS (Electrospray Ionization Mass Spectrometry) to match the theoretical molecular weight (742.29).
• Exceptional Solubility: Effortless to formulate with. Fully soluble in water at 100mg/ml (10%), creating clear, stable aqueous solutions.
• Formulation-Friendly pH: A 1% solution pH of 6.47 ensures high compatibility and stability within the most common cosmetic pH range (5.0-7.0).
• Reliable Sourcing: Available for bulk orders directly from the manufacturer, guaranteeing a traceable, stable, and consistent supply chain.

Key Technical Specifications (Copper Peptide COA)

We provide full transparency into our product quality. The specifications below are derived from a typical batch Certificate of Analysis (COA), demonstrating our commitment to precise and consistent quality control. We are a Copper Tripeptide-1 supplier that provides a full, batch-specific COA with every shipment.

Detection & Quality Assurance

In the high-value peptide market, quality is not just a specification—it is a guarantee. Our quality management system is built on precision and transparency, reflecting our commitment as a primary GHK-Cu manufacturer.

Purity and Identity Verification

Many suppliers test peptide purity using less accurate UV-Vis spectrophotometry, which can be misleading.

• Purity (HPLC): We exclusively use High-Performance Liquid Chromatography (HPLC). This advanced method separates, identifies, and quantifies the Copper Tripeptide-1 peak, ensuring you receive true ≥ 99% purity (99.12% typical). This means our product is free from significant synthesis-related impurities.
• Identity (ESI-MS): A blue powder is not enough. Every batch is verified using Electrospray Ionization Mass Spectrometry (ESI-MS) to confirm the exact molecular weight (742.29). This guarantees you have the correct, authentic Copper Tripeptide-1 molecule, not a counterfeit or a different complex.

Batch-to-Batch Consistency

As the original manufacturer, we control the entire synthesis and purification process from start to finish. This direct oversight allows us to maintain exceptional consistency in purity, copper content, color, and solubility. For formulators and brand owners, this translates to predictable performance, stable formulations, and reliable product efficacy from the R&D lab bench to full-scale production.

Applications & Formulation Guidelines

GHK-Cu is a versatile cosmetic ingredient suitable for a wide range of premium personal care products where high efficacy and a sophisticated “skin-repair” story are desired. Its compliance status makes it a globally accepted active.

• Premium Anti-Aging Formulations: (Serums, creams, eye contours) Ideal for products targeting the appearance of fine lines, wrinkles, and skin firmness.
• Soothing & Calming: (Post-procedure topicals, sensitive skin formulations) Excellent for formulations designed to calm the appearance of stressed, irritated, or compromised skin.
• Scalp & Hair Care: (Hair serums, scalp treatments) Used in advanced formulations to support a healthy scalp environment and improve the appearance of hair vitality and density.

Recommended Usage Levels & Incorporation

• Typical Concentration (Pure Powder): 0.05% – 0.2%
  • This translates to 500 – 2000 ppm.
• Formulation Method (Stock Solution): For easier and more accurate dosing, we recommend formulators first create a 1% stock solution.
  • How to make: Dissolve 1g of GHK-Cu powder in 99g of purified water. Due to its high solubility, it will dissolve quickly with simple stirring at room temperature.
  • How to use: This stable 1% blue solution can then be added to your final formulation at a rate of 1% – 10% (to achieve a final active level of 0.01% – 0.1% GHK-Cu). Add during the cool-down phase (below 40°C / 104°F).

Compatibility & Stability

Understanding stability is key to a successful GHK-Cu formulation.

pH Stability

GHK-Cu is most stable in formulations with a pH range of 5.0 – 7.0. Outside this range (in highly acidic or highly alkaline systems), the copper complex may destabilize, leading to color changes and a significant loss of efficacy. Our 1% solution pH of 6.47 is ideally centered in this stable zone, ensuring minimal impact on your final formulation’s pH.

Formulation Incompatibilities (Important)

To ensure product integrity, please observe the following guidelines:

• Strong Acids (e.g., L-Ascorbic Acid): DO NOT formulate GHK-Cu in the same aqueous phase with high-concentration ( >10%) L-Ascorbic Acid (Vitamin C). The low pH and high reactivity will rapidly degrade the peptide complex.
• Strong Chelating Agents (e.g., EDTA): EDTA, Disodium EDTA, and other strong chelators are designed to “steal” metal ions. They will break the GHK-Cu complex by binding to the copper ion, destroying the active’s structure and function.
• AHA/BHA: Use with caution. High concentrations or low pH systems (below pH 4.0) containing Glycolic or Salicylic acid may compromise GHK-Cu stability over time.
• Compatible With: GHK-Cu is generally highly compatible with Hyaluronic Acid, Niacinamide, Panthenol (B5), and most non-peptide moisturizing factors.

Safety & Regulatory Compliance

This product is intended for cosmetic and personal care formulation use only.

• INCI Name: Copper Tripeptide-1
• CAS Number: 49557-75-7
• Regulatory Status: Copper Tripeptide-1 is listed for use in cosmetic applications in major global markets, including the USA, European Union (Cosing), and China (IECIC 2021).
• Safety: GHK-Cu is considered non-irritating and non-sensitizing at recommended cosmetic use levels. We provide a full MSDS (Material Safety Data Sheet) upon request.

Storage & Packaging

• Storage: Store in a cool, dark, and dry place. The powder is hygroscopic (as indicated by the Loss on Drying test). Keep the container tightly sealed at all times to protect it from moisture and light, which can degrade the product.
• Packaging: Standard packaging is 10g, 50g, and 100g in heat-sealed, light-blocking aluminum foil bags. 1kg options are available for bulk orders. As a bulk exporter, we can accommodate custom packaging solutions for large-scale production needs.

Frequently Asked Questions (FAQ)

Q: Are you a GHK-Cu factory or a trader?

A: We are the original manufacturer and direct supplier of GHK-Cu. We manage the entire synthesis, purification, and quality control (QC) process in-house, which is how we can guarantee the ≥99% HPLC purity and ESI-MS verified identity shown in our COAs.

Q: What is the difference between 98% and 99% HPLC purity?

A: While 98% is a common standard, our ≥99% grade (99.12% typical) represents a higher level of purification with fewer process-related impurities. For high-performance cosmetic formulations, this superior purity directly translates to higher efficacy, better safety, and more reliable formulation stability.

Q: How do I properly dissolve the GHK-Cu powder?

A: Our GHK-Cu is exceptionally water-soluble (≥100mg/ml). We recommend adding the powder slowly to your purified water phase (at room temperature) while stirring. It should dissolve quickly and completely, forming a clear, deep blue solution.

Q: Can I use GHK-Cu with Vitamin C?

A: We strongly advise against combining it in the same water phase with L-Ascorbic Acid due to pH and stability conflicts (see Compatibility section). However, it may be compatible with more stable Vitamin C derivatives (like SAP, MAP, or 3-O-Ethyl Ascorbic Acid), but we recommend performing your own stability testing.

Q: What documents do you provide with a purchase?

A: Every shipment includes a batch-specific Certificate of Analysis (COA) and a Material Safety Data Sheet (MSDS). A comprehensive Technical Data Sheet (TDS) is also available for download or upon request.

Q: What is the MOQ and lead time for bulk orders?

A: We offer flexible order quantities from R&D samples (10g) to bulk production (multi-kg). Please Request a Quote or contact our sales team for current pricing, MOQ, and lead times based on your location and volume needs.