Undenatured Type II Collagen

What is UC-II Collagen?

UC-II is the abbreviation of “Undenatured Type II Collagen”, which is usually derived from chicken breast cartilage and is a high-end raw material for joint health in dietary supplements.

Unlike ordinary hydrolyzed collagen, UC-II retains the natural triple helix structure, so it has an immunomodulatory effect in the body, which can help reduce joint inflammation and relieve joint pain.

• Appearance: White or off-white fine powder
• Odor: Characteristic protein odor
• Protein Content: ≥60%
• Assay of Mucopolysaccharides: ≥26%
• Particle Size: 100% pass through 80 mesh
• Certifications: GMP / ISO / HACCP / HALAL / KOSHER / FDA Compliant
• Form: Free-flowing powder suitable for capsules, tablets, and drink powders

Undenatured Type II Collagen (UC-II) helps promote cartilage regeneration, reduce joint inflammation, and improve flexibility and mobility, particularly in aging populations and active lifestyles.

Technical Specifications

Key Features

• ✅ Native collagen structure (undenatured)
• ✅ High bioavailability and functional activity
• ✅ ≥60% protein content for enhanced nutritional value
• ✅ Low fat and low ash content
• ✅ Strict microbiological and heavy metal limits
• ✅ Excellent solubility and easy formulation

Quality & Compliance

Our Undenatured Type II Collagen is manufactured in a GMP- and ISO-certified facility, adhering to global food and nutraceutical safety standards:

• Routine quality testing: HPLC, UV, Microbiology
• Complies with USP, EP, and CP monographs where applicable
• Third-party testing available for heavy metals, microbial load, and functional activity
• Fully documented with COA, MSDS, TDS, and spec sheet

Applications

Nutraceuticals

• Joint support supplements (capsules, tablets, softgels)
• Anti-inflammatory blends
• Sports nutrition recovery formulas
• Senior mobility supplements

Functional Foods

• Protein drinks & shakes
• Collagen-enhanced bars and snacks
• Powdered drink mixes

Pet Supplements

• Formulations for joint care in dogs, cats, and horses

Supply & Services

• Packaging:
  • 1kg aluminum foil bag
  • 25kg food-grade drum
  • Customized packaging on request
• Shelf Life: 24 months
• Storage: Store in a sealed container away from heat, moisture, and direct light
• Lead Time: 5–7 working days (in-stock)
• OEM/ODM Support: Available for bulk formulation and private label

Company Credentials

Xi’an Best Bio-Tech Co., Ltd. specializes in the research, development, and global supply of premium functional ingredients, including collagen, plant extracts, and superfood powders.

• Factory located in Yangling, China’s hub for nutraceutical production
• Serving 60+ countries with over 15 years of export experience
• Fully certified (ISO9001, HACCP, HALAL, KOSHER, FDA compliant)

Scientific Background

Undenatured Type II Collagen supports immune-mediated joint protection by inducing oral tolerance, reducing the body’s inflammatory response to collagen in the joints. Unlike hydrolyzed collagen, UC-II works at low dosages (typically 40mg/day) and has been clinically studied for osteoarthritis, rheumatoid arthritis, and sports injury recovery.

Reference: Lugo JP et al., “Undenatured Type II Collagen for joint support: A review of the clinical literature.” Int J Med Sci, 2016.

FAQ

1. What’s the difference between undenatured and hydrolyzed collagen?

Undenatured collagen retains its triple-helix structure and works through immune modulation, whereas hydrolyzed collagen is broken into peptides and primarily offers amino acid nutrition.

2. Is it suitable for vegans?

No — UC-II is typically derived from chicken sternum cartilage.

3. How should this ingredient be stored?

Keep it in a cool, dry, sealed container, away from moisture and light.

4. Do you provide small samples?

Yes — free samples are available for evaluation.