Quercetin vs. Fisetin: Which Flavonoid Offers Greater Health Benefits?

Flavonoids like Quercetin and Fisetin have gained serious traction in health circles for their wide-ranging benefits. They’re found in everyday foods, yet offer potential advantages that go beyond the basics—think cognitive support, anti-aging properties, and antioxidant defenses. But between the two, which one really delivers more bang for your buck?

What Is Quercetin?

Quercetin is a plant flavonoid commonly found in onions, apples, and berries. It’s best known for its antioxidant, anti-inflammatory, and antihistamine properties. It may support immune function, reduce allergy symptoms, and promote heart health.

• Reduces oxidative stress
• Helps manage inflammation
• May support cardiovascular wellness
• Improves endurance and exercise recovery

What Is Fisetin?

Fisetin is a less common, but arguably more potent, flavonoid found in strawberries, apples, and persimmons. It stands out due to its unique ability to act as a senolytic—meaning it helps remove aging cells, which can promote longevity and reduce chronic inflammation.

• Clears senescent (aging) cells
• Improves memory and brain function
• Potential anti-cancer effects
• Supports metabolic and insulin health

Head-to-Head Comparison

Which One Should You Choose?

If you’re looking for an immune booster or allergy relief, Quercetin is a strong candidate. On the other hand, if you’re focused on anti-aging, cognitive function, or longevity, Fisetin might be the better fit.

Interestingly, researchers at NOVOS Labs argue that Fisetin has superior senolytic effects and longer half-life in the body compared to Quercetin.

Potential Risks & Side Effects

• Both are generally well-tolerated in moderate doses
• High doses may cause digestive issues or interact with medications
• Always consult your healthcare provider before supplementing

Final Thoughts

Both Quercetin and Fisetin offer compelling health benefits—but they’re not interchangeable. Use them based on your personal health priorities. Ideally, talk with a health professional to see which one (or both) could be integrated into your supplement routine.